From 1872, this cartoon, The Darwinian Student's Afterdinner Dream, in Harpers Weekly, while not having much thematically to do with the Sequence does have some stylistic hints (in those swirling, growing, morphing images) at what was to come .

Then there are those that just play with the idea

For example the Darwin Awards logo (the awards exist for the "Honoring [of] those who improve the species by accidentally removing themselves from it,... thereby ensuring that the next generation is one idiot smarter")